Antidiabetic activity of the hydroethanolic extract of c. Traditionally, the plant is also used for treatment of diabetes. After acute toxicity test, the swiss albino mice were induced with alloxan to. Pdf antidiabetic activity of ethanolic extract of sesbania grandiflora. A comparison was made between the action of costus igneus extract and a known antidiabetic drug glibenclamide 600 gkg body wt. Aqueous extracts of zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. This observed antidiabetic activity of this extract might be due to their phytochemical constituents previously reported. For treatments, the concentration of aqueous extract was 400 mgkg body weight. Evaluation of antidiabetic activity of leaves and fruits. Antidiabetic activity of the compounds isolated from rhus mysorensis plant extract doi. Blood glucose level was monitored for next 4 hours after glucose loading 2 gmkg with interval of 1. However, due to the potential toxicity of the plant extract it must be prescribed with caution. The plants of artocarpus species have been used by traditional folk medicine in indonesia.
Evaluation of antidiabetic activity of plants used in western. The main objective of this work is to evaluate the in vitro anti diabetic activity of methanolic extracts of cinnamomum zeylanicum, piper betle, artocarpus heterophyllus and artocarpus altilis. Screening for antidiabetic activity of the ethanolic extract of. Repeated dose administration of alcoholic and hydroalcoholic extract showed significant hypoglycemic and antidiabetic activity at the end of 7th day. Pdf in vivo antidiabetic activity of capparis erythrocarpos.
The present work is to study for the first time the antidiabetic properties of aqueous extract of roots of anacyclus pyrethrum l. Evaluation of in vitro anti diabetic activity of selected. The studied plant extract contained alkaloids, flavonoids. Antidiabetic activity of different extracts of myrtus. Antidiabetic agents from medicinal plants bentham science. Thus, these data imply that the butanol fraction of a. Phytochemical and in vitro antidiabetic activity of. Antidiabetic activity of nymphaea pubescens ethanolic. Foeniculum vulgare, antidiabetic activity, aqueous extract, streptozotocininduced diabetic rats. Pdf antidiabetic activity of aqueous root extract of.
The present study was aimed to evaluate antidiabetic and antioxidant activity of aqueous extract of jackfruit. The findings from this study therefore support the folkloric usage of b. Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in nondiabetic subjects and the same result was seen in diabetic subjects. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin.
Antidiabetic activity and phytochemical screening of. Antidiabetic activity of ethanolic extract of hydnocarpus. Antidiabetic activity of mediumpolar extract from the leaves of stevia rebaudiana bert. Antidiabetic activity of methanolic extract of hibiscus cannabinnus in streptozotocin induced diabetic rats. Pdf antidiabetic activity and phytochemical screening of. Antidiabetic activity of terminalia catappa leaf extracts ijpt. Plants have been the primary source of drugs and many of the currently available drugs have been directly or indirectly derived from plants. The available drugs for diabetes, insulin or oral hypoglycemic agents have one or more side effects. A blood glucose lowering extract of a mixture of five plants in use by kuwaiti diabetics was studied for the identification of its active components. Antidiabetic activity of vinca rosea extracts in alloxan. In addition, the antioxidant actions of petal extract of safflower against formation of li. The leaves of this plant were investigated for its antidiabetic in vivo in stz induced diabetic rat model and to compare the same with.
Evaluation of antidiabetic activity of ethanolic extract. In the present study, the whole plant was selected in case of herbs, leaves and stem in case of shrubs and leaves in case of trees on the basis of availability of phytoconstituents. Antidiabetic activity and phytochemical screening of extracts. Antidiabetic activity of nymphaea pubescens ethanolic extract. In vitro and in vivo antidiabetic and antioxidant activities of. An analysis of antidiabetic activity of stevia rebaudiana. The main objective of this work is to evaluate the in vitro anti diabetic activity of methanolic. The plant extract was accessed for antidiabetic effect by both oral and intraperitoneal administration.
Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of the aqueous and 70% ethanol extracts on alloxaninduced diabetic mice. The methanolic extract at 500 mgkg dose level exhibited significant p activity. Please see the supplementary file for standards hplc chromatograms figure s1. Further, in vivo antidiabetic activity was assessed in streptozotocin. The rationale of the present study is to find out the level of efficacy and potency of the leaf extract in accordance with hypoglycemic activity. Antidiabetic activity and phytochemical screening of extracts from indonesian plants by inhibition of alpha amylase, alpha glucosidase and dipeptidyl peptidase iv. Both extracts were administered at the dose of 200 mgkg p. It is found growing in both natural and plantation forms in most of the parts of country. Dec 19, 2019 the study results revealed that the ethanolic extracts of both plants leaf extracts showed significant in vitro antioxidant and antidiabetic activity when compared with aqueous extracts. Only the extracts of myrrh and aloe gums effectively increased glucose tolerance in both normal and diabetic rats.
The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of. Introduction in folk medicinal practice many plants are used to treat diabetes mellitus in south india. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 gl. In many in stances the chemical constituent in the plant responsible for the biological activity has been isolated and identified, and information is also available concerning the mechan. The aim of this study was to investigate the antidiabetic activity of stem bark of berberis aristata dc familyberberidaceae extract in stzinduced diabetic albino wistar rats. Antidiabetic activity of insulin plant costus igneus leaf. The in vitro antidiabetic activity of the aqueous leaf extract and agnps was confirmed by non. Evaluation of antidiabetic potential of leaves and stem of flacourtia. An overview and future scope on traditionally used herbal. Determination of stevioside in plant material and fruit teas, journal of food composition and analysis. However, due to the potential toxicity of the plant extract. The selected plant extracts were studied for their effect on inhibition of glycosylation of haemoglobin and glucose transport across yeast cells. Introduction now a days medicinal plants are considered as an important therapeutic aid for reducing ailments of human being.
Animals were kept under close observation for 24 h after administering the extract, and then they were observed daily for 3 days for any change in general behavior andor other physical activities. The antioxidant and antidiabetic effects of its extracts are unclear. However, the glucose lowering potency of this plant extract was dose independent. Plant species with antidiabetic properties plant based medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001. Comparative antidiabetic activity of methanolic extract of operculina turpethum stem and root against healthy and streptozotocin induced diabetic rats. Evaluation of antidiabetic activity of biologically. There was a dosedependent increase in percentage inhibitory activity against alphaamylase enzyme. Mar 21, 2020 there exists a genetic predisposition to diabetes. The objective of present work was to evaluate the antidiabetic activity of ethanolic extract of whole plant of nymphaea pubescens eenp. The antidiabetic activity of ethanolic extract of whole plant of alternanthera sessilis linn.
From the mass spectrum of dv 1, it was observed that a molecular ion peak at signal mz 304. Most of these medicinal plants are scientifically validated for. The aqueous leaf extracts contained tannins, flavonoids, saponins, sterols, anthraquinones and alkaloids. All groups received one oral dose of 100, 250, 500, 650, 800, 950, and 1100 mg of plant extract kg body weight. The eenp extract established a effective inhibitory activity on. Alphaamylase inhibitory activity alpha amylase ec 3. Strong medicinal systems like ayurveda, unani and chinese, are still promising and has been practised over 1500 years.
Abutilon antidiabetic activity pdf buecher wuermer. Evaluating phytochemical and antidiabetic activity of. The extract and solvent fractions were prepared as described by teke et al. Isolation and characterization of antidiabetic compound from dregeavolubils benth. Ajuga remota, antidiabetic activity, blood glucose level, diabetes mellitus, glibenclamide, phytochemical screening.
Physalis minima is widely used in indian medicine by the tribal communities to treat. Antidiabetic activity of aqueous and methanol extract and fractions of gongronema latifolium leaves in alloxan diabetic rats p. Medicinal plants with potential antidiabetic activity a. Antidiabetic and antihyperlipidemic activity of piper longum. The dose of each extract was calculated according to body weight before administration to the diabetic rats.
In vitro and in vivo antidiabetic effect of extracts of. After 7 days the extract was filtered through muslin cloth and marc was discarded. Aqueous leaf extract of the plant has been studied for its antidiabetic effect in alloxaninduced diabetic rats 15, 16. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Antioxidant and antidiabetic activities of methanolic. The measurement of the antiradical activity of the plant extracts was carried out by the test with 2,2diphenyl1picrylhydrazyl dpph according to the method of parejo et al. Evaluation of antidiabetic activity of medicinal plant.
Aegle marmelos, alloxan, antidiabetic, hyperglycemia. These results suggest that aqueous and hydroalcoholic extract possess antidiabetic activity. Antidiabetic activity of mediumpolar extract from the leaves. Anti diabetic medicinal plants open access journals. Determination of in vitro antidiabetic effects of zingiber. Eeas was investigated in a model of streptozotocin induced diabetes in rats. The ethanolic extract at high dose 400 mgkg exhibited.
The aim of this research was to investigate antidiabetic activity of costus igneus also known as insulin plant leaves extracts in alloxan induced diabetic albino rats. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. Stzinduced diabetic mice showed significant p extract showed significant p extracts to inhibit glucose diffusion into the external solution was investi gated at set time intervals gallagher et al. The remaining components, gum olibanum,nigella sativa seeds and gum assafoetida were without effect. Different types of extracts from different part of plant were used for different activities e. Potential antidiabetic activity of extracts and isolated. The prevalence of diabetes mellitus dm is increasing with ageing of the population and life style changes associated with rapid urbanization and westernization. The ethanolic leaf extract of matelea denticulata exhibited superior in vitro free radical scavenging and antidiabetic activity amongst the other extracts. Antidiabetic effect of hydroalcoholic extract of carthamus.
Acute toxic class method is a stepwise procedure with use of three animals of a single sex per step. In the stzinduced diabetic mice, both extracts showed a strong antihyperglycemic activity, with the group receiving 50 mgkg of ethanol extract and the group receiving 50 mgkg of aqueous extract presenting 64. By acute toxic class method swiss albino mice of female sex weighing 2025gms were used for the study. Nair1, vaibhavi kavrekar1, anshu mishra1 1 department of biotechnology, mount carmel college, bangalore, karnataka, india abstract. In vivo antidiabetic activity of aqueous extract of. The observations confirm that methanolic extract of the leaf and stem of the plant has antidiabetic activity and is also involved in correction of altered biological. The extract of corni fructus has potent antidiabetic activity towards streptozotocin.
The antidiabetic effects were found to be dosedependent. Evaluation of in vitro anti diabetic activity of selected plant extracts sindhu. The entire plant or its different parts can be used in the form of a whole plant, crude extract, and aqueous decoctions. More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity 2635 examples of herbal medicines with proven anti diabetic activity plant part used. Possible therapeutic potential for diabetic complications curr diabetes rev 2012. Pdf herbal medicines are commonly measured to be fewer toxic and also free from side effects, than synthetic ones. Antidiabetic and antihyperlipidemic activities of the leaf. This study aims to examine the antioxidant and antidiabetic effects of 70% ethanolic extract of syzygium polyanthum wight leaf. Antidiabetic activity of insulin plant costus igneus leaf extract in diabetic rats.
Antidiabetic activities of chromolaena odorata methanol. Investigation of antidiabetic effect of ethanolic extract. Okolo rural dwellers in nigeria often resort to herbal remedy and dietary control in the treatment of diabetes mellitus dm. Hence, this study investigated the antidiabetic properties of the methanol root extract of chromolaena odorata and its effect on biochemical parameters in alloxan induced diabetic rats. Phytochemical screening and antidiabetic effect of. Presenting antidiabetic plants in iranian traditional medicine. Hence, the chemical constituents of the plant extract might help in preventing diabetic complications and may serve as an alternative in the present armamentarium of antidiabetic drugs. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenge according to who recommendations. In vivo and in vitro antidiabetic activity of terminalia. Antidiabetic activity of aqueous extract of sigesbeckia orientalis st. Further, aqueous extract of terminalia paniculata bark contains active biomarkers which may possibly be responsible for the antidiabetic activity of terminalia paniculata bark. May 02, 2017 treatment with the antidiabetic drug, glibenclamide 10 mgkg body weight lowered blood glucose level by 51. Evaluation of antidiabetic activity of aqueous and ethanolic extracts.
The observed fragmentation pattern shows that the similarity of a compound having an aromatic origin. Chromolaena odorata is a medicinal plant whose root has not been reported for detailed antidiabetic properties. Cinnamomum cassia or chinese cinnamon is one of the fundamental herbs in traditional chinese medicine. In addition, dm is a group of diseases characterized by chronic hyperglycemia due to deficiency of insulin action, a common basis of diabetes that leads to characteristic abnormalities in the metabolism. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocininduced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity. In vitro antidiabetic activity of psidium guajava leaves. In vitro antidiabetic activity and mechanism of action of. First, we observed the antidiabetic activity of aqueous extract of the entire plant leaves, twigs and roots of a. The present study was carried out to evaluate the antidiabetic activity of acalypha indica ethanolic extract of whole plant of in alloxan induced diabetic rats for 7 days. A read is counted each time someone views a publication summary such as the title, abstract, and list of. Diabetes or obesity causes substantial morbidity, mortality and longterm complications, and remains an important risk factor for cardiovascular disease 1. Toevaluate antidiabetic activity of chloroxylon swietenia in stz induced diabetes in. The effect of the extract supported the traditional claim of the plant.
Blume was selected which was traditionally used for various ailments like leprosy, antioxidant, secondary syphilis, rheumatism ophthalmic, the folklore claim of hydnocarpus wightiana blume shows that it is having antioxidant properties and antidiabetic activity. Antidiabetic activity of alcoholic extract of cinnamomum. An acute oral toxicity study was performed as per oecd guidelines 423. Further study to substantiate the use of the plant as antidiabetic is recommended. Molecules free fulltext antidiabetic activity and metabolic. The selected plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using in vitro assays such as. Investigation of antidiabetic effect of ethanolic extract of. Ajuga remota benth is traditionally used in ethiopia for the management of diabetes mellitus. Diabetes mellitus dm is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin action, insulin secretion from pancreatic beta cells, or both. An analysis of antidiabetic activity of stevia rebaudiana extract on diabetic patient neha mishra. Bertoni on alloxaninduced diabetic rats bertoni on alloxaninduced diabetic rats himanshu misra, 1, 2 manish soni, 3 narendra silawat, 4 darshana mehta, 1 b. Antidiabetic activity medicinal plant aegle marmelos. Antidiabetic activity of syzygium cumini and its isolated compound against streptozotocininduced diabetic rats.
The observed hypoglycemic activity could be associated with the phytochemicals present in this plant extract. To evaluate the glucose uptake of antidiabetic activity crude nhexane, ethanol, ethanol and aqueous leaf extracts of p. Antidiabetic activity of the compounds isolated from. In vitro study results scientifically supported the terminalia paniculata bark in vivo antidiabetic activity. The antidiabetic activity in plants may be attributed to the presence of phenolic and flavonoid compounds. Antioxidant activity was done by dpph diphenyl picrylhydrazyl assay method, meanwhile antidiabetic activity was done by in vivo studies using male rats wistar strain. In vitro free radical scavenging and antidiabetic activity of. Evaluation of antidiabetic activity of euphorbia hirta linn. The in vivo anti diabetic activity was screened in albino diabetic induced rats 7.
In our study, the butanol fractions of selected plant species generally have been found more active than other fractions, indicating that compounds having antidiabetic activity are polar in nature which established the significant correlations of polyphenolic and flavonoids to lower down the. Decreased blood glucose levels of the test animals showed that the extract exhibited significant antidiabetic activity, when compared to diabetic control group. It was extracted up to one week with daily 2 hours stirring with a mechanical stirrer. Introduction diabetes mellitus is the one of the challenging health. Effect of ethanolic extract of cinnamomum zeylanicum leaves on fasting blood glucose level of alloxaninduced diabetic rats subacute studies. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Journal of oen a c e biopharmaceutics and therapeutic. In vitro investigation of antidiabetic potential of selected. Hence, the present study is planned to investigate the antioxidant and antidiabetic effects of methanolic extracts. The ethanolic extracts and the hexane and chloroform fractions of leaves and fruit peels showed promising antidiabetic activity in stzs model. The extract was studied for their effect on inhibition of. Potential antidiabetic activity of medicinal plants a.
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